Last week he beat his mentor Jose Mourinho as Derby defeated Manchester United on penalties in the third round of the competition at Old Trafford.
The Chelsea-Derby tie is one of 12 to be played in the week commencing October 29 with Tottenham versus West Ham and Burton Albion versus Nottingham Forest two derby games.
Blackpool, one of two League One sides left in the competition alongside Burton, have been handed a trip to Arsenal while holders Manchester City host Fulham.
The other ties see Middlesborough play Crystal Palace, Norwich City travel to Bournemouth and Leicester City play the winners of either Everton or Southampton, who play next week.
Fourth round in full:
Manchester City vs Fulham
AFC Bournemouth vs Norwich City
Arsenal vs Blackpool
Leicester City vs Everton/Southampton
West Ham United vs Tottenham Hotspur
Middlesbrough vs Crystal Palace
Burton Albion vs Nottingham Forest